Help Prevent the Flu After Exposure 1

XOFLUZA is the first and only single-dose post-exposure prophylaxis medication (patients aged ≥12 years) 1,11


In patients (aged ≥12 years) who were given single-dose XOFLUZA, their risk of contracting the flu after contact with an infected household member was reduced by 90% compared to patients who received placebo (1% XOFLUZA [95% CI of 0.4, 3.3] vs 13% placebo [95% CI of 9.6, 17.5]), corresponding to an estimated adjusted risk ratio of 0.10 (95% CI of 0.04, 0.28), based on randomization factors. 1,11

In Trial 4, conducted in Japan, 607 subjects (XOFLUZA n=303, placebo n=304) ≥12 years of age were randomized to receive a single oral dose of XOFLUZA, based on body weight and age, or placebo. In total, 374 subjects were treated with XOFLUZA and 375 with placebo. Subjects aged ≥12 years received 40 mg or 80 mg of XOFLUZA according to body weight. Subjects aged <12 years were dosed according to body weight. Subjects were household members of influenza-infected index patients and were required to have lived with the influenza-infected index patient for ≥48 hours. Index patients were required to have onset of symptoms for ≤48 hours. The primary efficacy endpoint was the proportion of household subjects who were infected with influenza virus and presented with fever and ≥1 respiratory symptom (cough or nasal discharge/nasal congestion assessed by the subject as moderate or severe) from day 1 to day 10. The proportion of subjects ≥12 years of age who met the primary endpoint was 1% (95% CI: 0.4, 3.3) in the XOFLUZA group and 13% (95% CI: 9.6, 17.5) in the placebo group, corresponding to an estimated adjusted risk ratio of 0.10 (95% CI: 0.04, 0.28), based on randomization factors. 1,11
 
XOFLUZA keeps flu treatment simple with one single dose compared to 10 doses with oseltamivir for the treatment or post-exposure prevention of the flu. 1,2 Learn more
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The Burden of the Flu

Most people who get the flu recover in 3 to 14 days, but this isn't the case for all patient types. 4,10

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Treatment in a Single Dose

Keep it simple with a full course of treatment in a single dose. 1