Flu Symptom Relief in Just 2.3 Days 1

Alleviation of symptoms in otherwise healthy patients (aged ≥12 years) treated with XOFLUZA 1


33% faster alleviation of flu symptoms (in patients aged ≥12 years) with single-dose XOFLUZA compared with placebo. 1

 

In Trial 1, conducted in Japan, subjects aged 20 to 64 years received XOFLUZA 40 mg (n=100) or placebo (n=100). The median value of the primary endpoint of time to alleviation of symptoms (TTAS) with XOFLUZA was 50 hours (95% CI: 45, 64) vs 78 hours (95% CI: 68, 89) with placebo. In Trial 2, conducted in the United States and Japan, subjects aged 12 to 19 years received either XOFLUZA (n=80) or placebo (n=38); subjects aged 20 to 64 years received either XOFLUZA (n=375), oseltamivir (n=377), or placebo (n=192). In total, 455 subjects were treated with XOFLUZA, 230 with placebo, and 377 with oseltamivir. In subjects aged 12 to 64 years, the median value of the primary endpoint of TTAS with XOFLUZA was 54 hours (95% CI: 50, 59) vs 80 hours (95% CI: 73, 87) with placebo. TTAS in both Trial 1 and Trial 2 was defined as the time when all 7 symptoms (cough, sore throat, nasal congestion, headache, feverishness, myalgia, and fatigue) had been assessed by the subject as none or mild for a duration of at least 21.5 hours. 1,3

In a secondary endpoint in Trial 2, in subjects ≥20 years of age, reduction of duration of flu symptoms was 54 hours for both XOFLUZA and oseltamivir. 1,3

TTAS = time to alleviation of symptoms. 


42% (1.6 days) faster relief from flu symptoms in adolescent patients (aged ≥12 to 17 years) with single-dose XOFLUZA compared with placebo. 1

In Trial 2, for subjects aged 12 to 17 years, TTAS was achieved 39 hours (1.6 days) faster with XOFLUZA (n=63) when compared with placebo (n=27) (median time of 54 hours [95% CI: 43, 81] vs 93 hours [95% CI: 64, 118]). 1

 

Single-dose XOFLUZA can help treat the flu in your patients at high risk for developing complications. 1
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XOFLUZA® (baloxavir marboxil) Safety Icon

Safe and Well Tolerated

Single-dose XOFLUZA was safe and well tolerated in clinical trials. 1

XOFLUZA® (baloxavir marboxil) Single Dose Icon

Treat in a Single Dose

XOFLUZA is the first and only single-dose oral antiviral for the flu. 1